Antaeus Labs' NEW Talos: The ULTIMATE Cycle Support! Antaeus Lab's NEW Talos was a mythological figure in ancient Greece – a giant man of bronze who protected the shores of Crete from invaders. Now you can harness the power of Talos to support your cardiovascular system. The Talos formula promotes cardiovascular health in all users, though it is specifically designed to help combat the negative effects of exogenous administration of androgens. Talos seeks to combat the adverse health effects of self-administered anabolic steroids, designer steroids, and prohormones with a combination of antioxidants, vitamins, and potent herbal extracts. Black Rice Extract, 25% Anthocyanins (1300mg per recommended daily dose. It has long been known that androgens cause an adverse shift the ratios of lipoproteins; causing an increase in low-density lipoproteins (LDL) and a reduction in high-density lipoproteins (HDL).  This is due to an increase in postheparin plasma hepatic triglyceride lipase (HTGL) activity; HTGL is the enzyme responsible for the catabolism of HDL.  High LDL and low HDL levels are associated with atherosclerosis and heart disease. Anthocyanins have been shown to increase HDL and reduce LDL concentrations in humans,  which may be due to the inhibition of plasma cholesteryl ester transfer protein (CETP), an enzyme which transfers cholesterol from HDL cholesterol to very low density or low density lipoproteins.  There's also evidence that the hypolipidemic effects of anthocyanins may be due to increased CYP7A1 expression due to agonism of LXRα.  "Our results suggest that anthocyanin supplementation in dyslipidemic patients has a beneficial effect on the lipoprotein profile, which includes a decrease in LDL-cholesterol and an increase in HDL-cholesterol concentrations."  SAMe (400mg from 800mg S-Adenosyl-L-Methionine Disulfate Tosylate) Soon after the introduction of oral (17a-alkylated) steroids it became apparent that excessive doses or prolonged use can be deleterious to liver function,  and since then there have been several case studies of jaundice and liver failure secondary to oral steroid use – both self-administered  and in the clinical setting.  The hepatotoxic effects of oral androgens are of a primarily cholestatic nature. S-adenosylmethionine is an endogenous methyl group donor and precursor to glutathione, which may be able to prevent androgen-induced cholestasis and liver injury. SAMe can inhibit bile acid-induced hepatocyte apoptosis,  downregulates expression of the inflammatory cytokine TNF-alpha,  and can reduce oxidative stress via glutathione replenishment,  which may also play a role in ameliorating the effects of cholestasis.  SAMe has been studied extensively as a safe and effective treatment for pregnancy-induced cholestasis,  and, in a case study, was even shown to reverse severe androgen-induced cholestasis.  Due to its distinct mechanism of action, it has an additive effect when used alongside UDCA/TUDCA.  As a direct precursor to glutathione and an inhibitor of TNF-alpha and NF-Kb, the benefits associated with SAMe use are not limited to hepatoprotection. It is also in wide use as a general antioxidant and anti-inflammatory. Ubiquinone (300mg) Coenzyme Q10 is an essential component of the production of cellular energy. Supplementation has been shown to have a host of benefits, including lowering blood pressure, without significant side effects.  It can also maintain heart health by functioning as an antioxidant. By lowering the susceptibility of LDL to oxidation, it may reduce the atherosclerotic (artery-hardening) effects of LDL ("bad cholesterol").  "Our data support the concept that the CoQ10 level of the LDL subfractions is important in minimizing susceptibility of LDL subfractions to oxidation."  Astilbin (200mg) Anabolic steroids have been shown to increase blood pressure.  Androgens stimulate vascular production of 20-hydroxyeicosatetraenoic acid (20-HETE), which induces endothelial angiotensin-converting-enzyme (ACE), leading to aldosterone secretion, vasoconstriction, and elevations in arterial blood pressure.  This is supported by observations of elevated aldosterone levels in steroid-using bodybuilders.  Astilbin is a potent, naturally-occurring ACE inhibitor.  ACE inhibitors reduce the production of angiotensin II, resulting in lower blood pressure and improved potassium retention and sodium excretion. Trans-Resveratrol (200mg) The naturally-occurring grape-derived antioxidant and phytoestrogen trans-resveratrol is believed to be cardioprotective through a number of mechanisms; amongst other things, it inhibits lipid peroxidation, induces vasorelaxation, and limits oxidative damage through the reduction of reactive oxygen species (ROS).  "Resveratrol, a grape polyphenol, has shown considerable promise as a therapeutic agent in the treatment of liver ailments. Several studies have highlighted the hepatoprotective properties of resveratrol. Resveratrol has been shown to prevent hepatic damage because of free radicals and inflammatory cytokines, induce anti-oxidant enzymes and elevate glutathione content."  Salicylate (175mg): Administration of anabolic steroids or prohormones enhances platelet aggregation.  Salicylic acid decreases platelet aggregation by inhibiting the formation of thromboxane A2,  which may reduce the risk of blood clots, heart attack and stroke.  B9, B6, and B12 (2mg, 60mg, 250mcg respectively): Androgens like testosterone have been shown to increase levels of homocysteine,  and the self-administration of anabolic steroids can increase homocysteine levels dramatically.  Homocysteine damages the structure of the arteries, and hyperhomocysteinemia (high homocysteine levels) is a strong risk-factor for cardiovascular disease, blood clots, and strokes.  Folic acid (B9), pyridoxine (B6), and cobalamin (B12) reduce the levels of homocysteine.  Astaxanthin (16mg): Astaxanthin promotes healthy lipid metabolism as an antioxidant,  as a PPAR-α agonist,  and also by promoting expression of ATP-binding cassette transporters A1 and G1 (ABCA1/G1).  ABCA1 and ABCG1 mediate the efflux of cholesterol; helping to remove lipids from cells as the initial step in reverse cholesterol transport (RCT). RCT is the process by which cholesterol is shuttled back to the liver by HDL.  "RCT is a pathway that transports cholesterol from extrahepatic cells and tissues to the liver and intestine for excretion. By reducing accumulation of cholesterol in the wall of arteries, RCT may prevent development of atherosclerosis. Cholesterol efflux, part of the RCT process, is a major process by which macrophages within the vessel wall secrete cholesterol outside cells."  Talos Supplement Facts Serving Size: 1 Capsule Servings per Container: 120 Amount Per Serving % Daily Value Black Rice Extract (25% Anthocyanins) 333 mg ** S-Adenosyl-L-Methionine Disulfate Tosylate (SAMe) 100 mg ** CoQ10 (As Ubiquinone) 75 mg ** Astilbin 50 mg ** Resveratrol 50 mg ** Salicylate 45 mg ** Vitamin B6 15 mg 750% Astaxanthin 4 mg ** Folic Acid 1 mg 250% Vitamin B12 66 mcg 1,100% * Percent Daily Values are based on a 2000 calorie diet. ** Percent Daily Values not established. OTHER INGREDIENTS: Gelatin, Silicon Dioxide, Microcrystalline Cellulose. Talos Directions: As a dietary supplement, take two capsules in the morning and two in the evening. Take with food, perferably with a high-fat meal. Do not exceed six (6) capsules daily. Talos WARNING: This product is for healthy adults over 18 years of age. Do not exceed recommended dosage. Consult a physician before using this or any dietary supplement. Do not use if you have any pre-existing medical condition or are taking any medication without consulting your physician. Store in a cool, dry place away from children. References:  Krüskemper HL. Anabolic steroids. Academic Press; 1968. p63  Applebaum-Bowden D, Haffner SM, Hazzard WR. The dyslipoproteinemia of anabolic steroid therapy: Increase in hepatic triglyceride lipase precedes the decrease in high density lipoprotein2 cholesterol. Metabolism. 1987 Oct;36(10):949–52.  Zhu Y, Ling W, Guo H, Song F, Ye Q, Zou T, et al. Anti-inflammatory effect of purified dietary anthocyanin in adults with hypercholesterolemia: A randomized controlled trial. Nutr Metab Cardiovasc Dis. 2012 Aug 17;  Qin Y, Xia M, Ma J, Hao Y, Liu J, Mou H, et al. Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects. Am. J. Clin. Nutr. 2009 Sep;90(3):485–92.  Wang D, Xia M, Gao S, Li D, Zhang Y, Jin T, et al. Cyanidin-3-O-β-glucoside upregulates hepatic cholesterol 7α-hydroxylase expression and reduces hypercholesterolemia in mice. Mol Nutr Food Res. 2012 Apr;56(4):610–21.  WERNZE H. Clinical research on the problem of liver damage by certain androgenic and anabolic steroids. Dtsch. Med. Wochenschr. 1960 Dec 16;85:2237–42.  Krishnan PV, Feng Z-Z, Gordon SC. Prolonged intrahepatic cholestasis and renal failure secondary to anabolic androgenic steroid-enriched dietary supplements. J. Clin. Gastroenterol. 2009 Aug;43(7):672–5.  Westaby D, Ogle SJ, Paradinas FJ, Randell JB, Murray-Lyon IM. Liver damage from long-term methyltestosterone. Lancet. 1977 Aug 6;2(8032):262–3.  GORDON BS, WOLF J, KRAUSE T, SHAI F. Peliosis hepatis and cholestasis following administration of norethandrolone. Am. J. Clin. Pathol. 1960 Feb;33:156–65.  Benz, Angermüller, Klöters-Plachky, Sauer, Stremmel, Stiehl. Effect of S-adenosylmethionine versus tauroursodeoxycholic acid on bile acid-induced apoptosis and cytolysis in rat hepatocytes. European Journal of Clinical Investigation. 1998;28(7):577–83.  Ansorena E, García-Trevijano ER, Martínez-Chantar ML, Huang Z-Z, Chen L, Mato JM, et al. S-adenosylmethionine and methylthioadenosine are antiapoptotic in cultured rat hepatocytes but proapoptotic in human hepatoma cells. Hepatology. 2002;35(2):274–80.  Yi-Sheng Liu, Wei Cai, Sheng-Mei Wu, Long-Hua Qian. Effect of S-adenosylmethionine on total parenteral nutrition-associated cholestasis. World J Pediatr 2007;3(3):218-221  Purohit V, Abdelmalek MF, Barve S, Benevenga NJ, Halsted CH, Kaplowitz N, et al. Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. Am. J. Clin. Nutr. 2007 Jul;86(1):14–24.  Chawla RK, Watson WH, Eastin CE, Lee EY, Schmidt J, McClain CJ. S-adenosylmethionine deficiency and TNF-alpha in lipopolysaccharide-induced hepatic injury.