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BLOODSHR3D (RAW EDITION) BY OLYMPUS LABS Olympus Labs has already covered the fat burning category with IGNIT3, a potent and effective supplement that targets 5 fat burning pathways, but it is time for the next innovation in weight loss supplementation.. As perfect as IGNIT3 may seem, it has one shortcoming is a capsule supplement. Why that is an issue? There are limitations on the ingredients that can be used in terms of taste and dosage since no one wants to take dozens of capsules on a daily basis. Most companies resolve this problem by underdosing most, if not all, of the ingredients in their fat burner. Those who have used IGNIT3 can TEST1FY that Olympus Labs takes no shortcuts. Another drawback of a capsule product is it can’t taste delicious. It would be great to enjoy a tasty drink that helps you to get shredded! The DemiGod R&D team took on this very challenge, to design a powdered fat burner on the same level as IGNIT3. Spoiler Alert:They nailed it! A new thermogenic powerhouse has been born with 8 ingredients all perfectly dosed to get you shredded to the bone. Olympus Labs understands the blood and sweat that you pour into the battle to achieve the perfect physique. To that end, we are proud to present the latest innovation in thermogenic supplementation, BLOODSHR3D! BLOODSHR3D is jam packed with all the ingredients you need to get ripped in two matrices that will deliver results. The Extreme Energy, Focus and Thermogenic Matrix features a potent 1-2 punch with Eria Jarensis and J. Regia. Since Olympus Labs uses only the most pure and potent extracts a full serving of these ingredients in BLOODSHR3D will hit hard and elicit an insane amount of energy and focus. It will also kickstart the fat burning process because these two ingredients act upon the central nervous system to induce thermogenesis. With the thermogenic engine in overdrive, let's slam on the accelerator with The Maximum Lipolysis Activation Blend. It consists of 250mg caffeine, 1,000mg of Green Coffee Bean Extract, 100mg Rhodiola Rosea, 400mg Rutin and 100mg Vanillin. The constituents of this blend will work in tandem to stimulate energy metabolism and promote fat loss to get you shredded! As aforementioned, BLOODSHR3D will be a powdered supplement. Olympus Labs understands that flavour is important and we are committed to provide a delicious drink that will make fat burning a breeze. However, it is not just a tasty drink, it is primarily a thermogenic powerhouse designed to incinerate fat just like its sister product, IGNIT3. One serving is split into a 2 scoop serving size for ultimate dosing flexibility. Even at 1-1.5 scoops, BLOODSHR3D has adequate amounts of each ingredient to yield results, which if dosed in that manner would yield 45-60 servings. Olympus Labs’ motto of Innovation, Value and Results in action! Extreme Energy, Focus and Thermogenic Matrix Olympus Labs uses two very potent stimulants; Eria Jarensis and J. Regia to deliver an extreme increase in energy and focus. Furthermore, these ingredients are adrenergic substances which act upon the sympathetic nervous system to activate a sequence of nerve cell firing and a chemical release of epinephrine (adrenaline), norepinephrine in the blood stream. The release of these chemicals will elicit an intense thermogenic response and can be utilized for fat loss. Wait, this blend of ingredients looks very familiar. Well it should, because it was the same stimulant blend that Olympus Labs used in the popular capsule fat burner, IGNIT3, with one key omission. BLOODSHR3D - WAR EDITION does not contain Rauwolscine, also known as α-yohimbine. BLOODSHR3D - WAR EDITION was conceived to allow our international customers access to this potent and effective supplement. However, domestic DemiGods who have issues tolerating forms of yohimibine have another option as well. With BLOODSHR3D - WAR EDITION Olympus Labs ensures that no DemiGod is left behind. Eria Jarensis Eria Jarensis is an orchidaceae alkaloid, meaning it is derived from the orchid family of flowering plants. It is the only known plant derivative to contain N-phenethyl dimethylamine. Phenethylyamines (PEA) Increases levels of epinephrine and norepinephrine that can stimulate beta-adrenergic receptors located on adipose (fat) tissue to release fatty acids into circulation as a fuel source. However, PEAs effects are relatively short-lived because the compound is broken down by the MAO-B enzyme within hours. N-Phenethyl dimethylamine rectifies that issue so you can realize the thermogenic benefits without having to dose the ingredient every few hours for it to be effective as you would PEA. Therefore, Eria Jarensis has become popular as a supplement for its energy and thermogenic benefits. J.REGIA J.Regia is a source of various psychoactive alkaloids and Olympus Labs uses a custom extract of it in BLOODSHR3D. Olympus Labs has established J. Regia as a premier energy boosting stimulant. Those who have used CONQU3R UNLEASHED, IGNIT3 or EL1XIR know how remarkable this ingredient can be. It is also becoming common knowledge that J. Regia has potent focus and mood elevating benefits. It has also been observed to suppress appetite so can be useful when dieting. Therefore, it is only logical that we utilize this exceptional ingredient in BLOODSHR3D. Maximum Lipolysis Activation Blend Although the previous matrix was duplicated from the best capsule fat burner available, IGNIT3, with the exception of the caffeine.the rest of the formula is quite different. This matrix is primarily focused with stimulating lipolysis, the decomposition of stored fat. This process activates enzymes that increase production of cyclic adenosine monophosphate (cAMP) which activates protein kinase A. The secondary objective of this blend is to increase energy expenditure to ensure those fatty acids are shed. The Maximum Lipolysis Activation Blend is comprised of five ingredients that achieve these two objectives; 250mg of caffeine, 1,000mg Green Coffee Bean Extract, 100mg Rhodiola Rosea, 400mg Rutin and 100mg Vanillin. Caffeine Caffeine is a tried and true supplement that has been studied extensively. It is known to increase focus, mental alertness and reduces symptoms of fatigue due to its ability to produce higher dopamine levels in areas of the brain that are linked to “attention”. It also increases energy expenditure and lipolysis so it is a perfect addition to the Maximum Lipolysis Activation Blend. A double-blind study in healthy subjects who had moderate habitual caffeine consumption investigated the effect on placebo and 100, 200, and 400 mg oral caffeine on energy expenditure, plasma concentrations of substrates and hormones, blood pressure, and heart rate. Caffeine dose dependently increased energy expenditure and the thermogenic response was positively correlated with the response in plasma caffeine (r = 0.52; p less than 0.018), plasma lactate (r = 0.79; p less than 0.000001), and plasma triglyceride (r = 0.53; p less than 0.02). These results indicate an increase in energy expenditure and thermogenic response from caffeine consumption. A study was conducted to determine the relationship between paraxanthine (caffeine's major dimethylxanthine metabolite) and free fatty acid (FFA) mobilization after intravenous caffeine administration. 10 men received a dose of 4mg of caffeine per kilogram of lean body mass. Venous blood samples were obtained before dosing and at multiple time intervals (5, 10, 15, 30, 45, 60, 90, 120, 150, and 180 minutes). Serum levels of FFA, glycerol, caffeine, and paraxanthine were determined in duplicate. Concentrations of FFA and glycerol were corrected for plasma volume changes. A high negative correlation was seen between decreases in caffeine and increases in FFA (r = -0.90) and a high positive correlation was seen between the appearance of paraxanthine and FFA (r = 0.93). It was concluded that paraxanthine may play a role in increased lipolysis after caffeine administration in humans. Green Coffee Bean Extract Green Coffee Bean Extract (GCBE) has developed somewhat of a poor reputation, largely because it was touted as a miracle weight loss supplement. Unfortunately, GCBE could not live up to these unrealistic expectations and further discredited when it was discovered that several studies were poorly designed and executed. Fortunately, most of those studies have been withdrawn and we are left with reliable data to form a new opinion of GCBE. So is it really a miracle weight loss supplement? No, but it can be an effective supplement when combined with other weight loss aids. Now that we have established what GCBE is not, let's discuss what it is. GCBE is derived from the green or raw coffee bean and contains several components including caffeine, theophylline and chlorogenic acid (CGA). Since CGA is found in the greatest amount in GCBE it has been the primary focus of research which has shown lipolytic and weight-loss properties. CGA is a polyphenol that has antioxidant properties and influences glucose, fat, and brain energy metabolism. One study concluded that the CGA component of GCBE clearly showed the release of free fatty acids. Olympus Labs uses GCBE containing 50% CGA, the highest extract available. A clinical study conducted found that supplementation with decaffeinated green coffee bean extract (GCBE), containing 45-50% Chlorogenic acid significantly reduced the progression of a loss in glucose-tolerance response caused by a high-fat diet. The study also found GCBE improved brain mitochondrial energy metabolism as determined by oxygen consumption rate. Follow-up gene expression profiling with Agilent whole-genome microarray revealed that the decaffeinated coffee treatment modulated a number of genes in the brain that are implicated in cellular energy metabolism. An in-vitro study found Chlorogenic acid significantly inhibited Glucose-6-phosphatase (Glc-6-P) hydrolysis in intact human liver microsomes in a competitive manner. Glc-6-P is a multicomponent system that exists primarily in the liver and catalyzes the terminal step in gluconeogenesis and glycogenolysis. The inhibition of Glc-6-P will have antidiabetic and glucose-lowering effects by reducing hepatic glucose production. Rutin Directions: Assess tolerance by taking (1) - (2) scoops 30-45 minutes before breakfast. Once tolerance has been assessed an additional scoop may be added. Do not exceed 3 scoops in any 24 hour period of time. References: Ali AT et al. Eur J Cell Biol. 2013 Jun-Jul;92(6-7):229-36. doi: 10.1016/j.ejcb.2013.06.001. Epub 2013 Jun 14. Adipocyte and adipogenesis. Hedman, K et al. Acta Chem. Scand. 23 (1969) No.9 Studies on Orchidaceae Alkaloids. Astrup A. Am J Clin Nutr. 1990 May;51(5):759-67. Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. Hetzler, RK et al. Journal of Applied Physiology Published 1 January 1990 Vol. 68 no. 1, 44-47. Effect of paraxanthine on FFA mobilization after intravenous caffeine administration in humans. Flanagan J et al. Phytother Res. 2014 Jun;28(6):946-8. doi: 10.1002/ptr.5085. Epub 2013 Dec 12. Lipolytic activity of Svetol®, a decaffeinated green coffee bean extract. Ho L et al. Nutr Neurosci. 2012 Jan;15(1):37-45. doi: 10.1179/1476830511Y.0000000027. Dietary supplementation with decaffeinated green coffee improves diet-induced insulin resistance and brain energy metabolism in mice. Henry-Vitrac C et al. J Agric Food Chem. 2010 Apr 14;58(7):4141-4. doi: 10.1021/jf9044827. Contribution of chlorogenic acids to the inhibition of human hepatic glucose-6-phosphatase activity in vitro by Svetol, a standardized decaffeinated green coffee extract. Punchal, S et al. J. Nutr. June 1, 2011. Vol. 141 no. 6 1062-1069, doi: 10.3945/jn.111.137877. Rutin Attenuates Metabolic Changes, Nonalcoholic Steatohepatitis, and Cardiovascular Remodeling in High-Carbohydrate, High-Fat Diet-Fed Rats Kauss, T et al. Arthritis Res Ther. 2008;10(1):R19. doi: 10.1186/ar2372. Epub 2008 Feb 6. Rutoside decreases human macrophage-derived inflammatory mediators and improves clinical signs in adjuvant-induced arthritis. Gao, M et al. Pharm Res. 2013 Nov;30(11):2940-50. doi: 10.1007/s11095-013-1125-1. Epub 2013 Jun 20. Rutin suppresses palmitic acids-triggered inflammation in macrophages and blocks high fat diet-induced obesity and fatty liver in mice. Sangin S et al. Nutrients 2015, 7(9), 8152-8169; doi:10.3390/nu7095385. Rutin Increases Muscle Mitochondrial Biogenesis with AMPK Activation in High-Fat Diet-Induced Obese Rats. Jinyong, Xu et al. Psychiatry Research. Volume 225, Issue 3, 28 Feb 2015, Pages 509–514. Vanillin-induced amelioration of depression-like behaviors in rats by modulating monoamine neurotransmitters in the brain Shyamala BN et al. J Agric Food Chem. 2007 Sep 19;55(19):7738-43. Epub 2007 Aug 24. Studies on the antioxidant activities of natural vanilla extract and its constituent compounds through in vitro models. Belagali, Y et al. Indian J Exp Biol. 2013 Apr;51(4):288-91. Effect of vanillin on lipid profile in a model of hyperlipidemia, a preliminary study. Tang X et al. British Journal of Pharmacology. 2013. doi:10.1111/bph.12611. Salidroside exerts angiogenic and cytoprotective effects on human bone marrow-derived endothelial cells via Akt/mTOR/p70s6K and MAPK signalling pathways. Li HB et al. Eur J Pharmacol. 2008 Jul 7;588(2-3):165-9. doi: 10.1016/j.ejphar.2008.04.036. Epub 2008 Apr 20. Salidroside stimulated glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase. Cifani C et al. Physiol Behav. 2010 Dec 2;101(5):555-62. doi: 10.1016/j.physbeh.2010.09.006. Epub 2010 Sep 15. Effect of salidroside, active principle of Rhodiola rosea extract, on binge eating. De Bock K. et al. International Journal of Sport Nutrition & Exercise Metabolism 14 (3), 298–307. 2004. Acute Rhodiola rosea intake can improve endurance exercise performance. Skarpanska-Stejnborn A et al. International Journal of Sport Nutrition and Exercise Metabolism, 2009, 19, 186-199 © 2009 Human Kinetics, Inc. The Influence of Supplementation With Rhodiola rosea L. Extract on Selected Redox Parameters in Professional Rowers Li HB et al. Eur J Pharmacol. 2008 Jul 7;588(2-3):165-9. doi: 10.1016/j.ejphar.2008.04.036. Epub 2008 Apr 20. Salidroside stimulated glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase.
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