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AdrenoSurge

Adaptogenic Stress Recovery Formula! Modern lifestyle realities often take a huge toll on our general health. A constant demanding cycle of sleep deficit, stimulant use (whether coffee or energy drinks), stress, overwork, etc ends up sapping our energy and sabotaging productivity and mood. While much of the popular supplementation promises revolve around a highly speculative condition of "adrenal fatigue", which has been conceptually abandoned by legitimate professionals who work closely with those displaying signs of adrenal dysfunction, a combination of factors does seem to manifest together. So where does that leave us for supplementation, and what is the point of AdrenoSurge? AdrenoSurge has been designed to support optimal adrenal activity for those displaying mild to moderate signs of dysfunction, acting primarily as an adaptogen. Some level of dysfunction is highly common in people with elevated stress levels, those that engage in vigorous exercise, regularly use stimulants, or do not get optimal duration and/or quality of sleep. Since a lot of people reading this fall into more than one of those categories, we feel that AdrenoSurge could help a high percentage of the health conscious population repair and recuperate from the daily damage done to the body; which will improve mental function, recovery from hard training, energy, stimulant sensitivity, and even body composition. Destructive Consequences of Modern lifestyle: Waking up tired Energy crash at a consistent, specific time during the day Energy surge during a consistent, specific time during the day (or night) Trouble falling asleep or staying asleep High blood sugar Frequent brain fog Frequent urination Lightheadedness when standing Loss of sensitivity to stimulants Salt cravings Sensitivity to light Asparagus Racemosus Extract 100mg Asparagus Racemosus is a particular species of asparagus used in Ayurvedic medicine for several purposes, including the alleviation of nervous disorders. Working through optimization of GABA and serotonergic signaling, it has been shown in research to have similar anti-anxiety properties to Diazepam without the sedating characteristics (1,2). It has been shown to decrease elevated plasma levels of corticosterone and norepinephrine, acting as an adaptogen to favorably modulate stress pathways (3). When rats were exposed to chemical and physical stressors, pre-treatment with AR prevented elevation in blood glucose (a common secondary effect of high cortisol), triglycerides and lipid peroxidation. Researchers labeled it as having anti-stress properties (4,5). Rats have also demonstrated better memory retrieval, and better performance during stressful maze tests (6). In addition, AR has been shown to be an antioxidant, hepatoprotective, and neuroprotective (6–8). Argyreia speciosa Extract 100mg A popular Ayurvedic Indian medicinal plant, Argyreia Speciosa (AS) has been studied for it's potential combatance against a long list of maladies; including decreased cognitive function, low sex drive, depressed immunity, depressed CNS function, liver damage, elevated ROS, inflammation, high blood sugar, diarrhea, pain, and GI distress. For our purposes, we will only be addressing a few specific potential benefits of AS supplementation. Similar to Asparagus Racemosus, AS has been shown to target and ameliorate several downstream effects of pathological stress including increased blood glucose, triglycerides, changes to the actual adrenal glands, as well as cortisol directly (9). Another study demonstrated the ability of AS to restore adrenal levels of cortisol and ascorbic acid levels after chronic, non-specific stress (10). AS has also been shown to be a liver protectant on par with Silymarin, analgesic, anti-inflammatory, gastroprotective, and has even been shown to prevent fat gain in overfed rats (11–14). Bacopa monnieri 20:1 100mg Bacopa monnieri (BM) has been extensively studied for its positive mental benefits; a recent 2014 meta-analysis suggested its consistent ability to improve cognitive ability, which tends to decline as a downstream result of the effects of stress (15). Under stressful, adverse conditions, BM has been shown to favorably modulate CYP450, SOD, and Heat Shock Proteins (an intracellular clean up crew) (16). Another 2014 study showed that in human subjects, during a stressful task, BM was able to exert positive effects on mood, a reduction in cortisol levels, and adaptogenic and nootropic effects (17). Rhodiola rosea (8% Rosavins) Rhodiola rosea (RR) is another well-studied herb with numerous potential benefits, with a recent meta-analysis concluding that it is able to improve both mental and physical performance during times of stress (18). It has been shown to prevent stress induced catecholamine release, which tends to be overactive in people with dysfunctional adrenals (19). In one study with over 100 participants, RR was shown to improve life-stress symptoms to a clinically relevant degree after only 3 days of supplementation, and the positive effects lasted until cessation of data collection at 4 weeks (20). It has also been shown to help subjects resist fatigue, increase the ability to concentrate, and decrease cortisol response to awakening stress in fatigued patients (21). Other studies have classified RR as having anti-anxiety, anti-depressant, and physical and cognitive impairment reduction attributes (22,23). Most products currently on the market are content with using anywhere between 1% and 3% Rosavins, while at the same time limiting dosage. AdrenoSurge is debuting a potent 8% Rosavin Rhodiola Rosea extract at a full 100mg dosage to maximize stress amelioration. Ashwagandha 20:1 100mg Ashwagandha is also considered an adaptogen, meaning it can help to dampen elevated cortisol, or help to boost low cortisol output, depending on what the body needs. Multiple studies in human subjects have demonstrated Ashwagandha's ability to help the body cope with the downstream effects of stress. In one such study lasting 60 days, ashwagandha was shown to improve resistance towards stress and improve self-reported quality of life (24). A similar study found that chronic stress caused high blood sugar, glucose intolerance, increased plasma corticosterone levels, cognitive deficits, immunosuppression, and depression, whereas ashwagandha was able to have significant anti-stress activity on these parameters (25). It has also been shown to be a GABA mimetic anxiolytic, anti-inflammatory, and improve energy and mitochondrial health (26). Bovine Adrenal Extract 10:1 125mg While the basis for this extract is largely based on volumes of feedback from functional medicine practitioners versus published data, most users tend to notice a "boost" even when taken as a single ingredient product. Users with suboptimal cortisol output will notice the greatest benefit; particularly those that have lose sensitivity to stimulants. According to adrenal dysfunction expert Dr. Michael Lam, "Many report a sense of increased energy when previously fatigued and a sense of calmness when previously anxious after taking glandular extracts". Evolvulus Alsinoide Evolvulus alsinoside (EA) is another potent adaptogen with several benefits (27). It has been shown to improve learning and memory in response to stress several recent studies (6,28,29). EA also demonstrates a nootropic effect that appears to be further enhanced when combined with Bacopa (30). EA appears to alleviate several downstream effects of stress aside from learning impairment, such as oxidative load, anxiety, and CNS depression (29,31). And like Argyreia and Ashwagandha, EA is also able to normalize high blood sugar and elevated plasma corticosterone levels (32,33). Conclusion In summary, AdrenoSurge offers a multi-angle approach to help encourage optimal adrenal function while ameliorating potential negative downstream effects of the body's stress response. Coupled with appropriate lifestyle adjustments like reducing stimulant and alcohol intake and normalizing sleep patterns, AdrenoSurge should be a potent weapon in anyone's toolbox looking to optimize long term health, energy levels, cognitive function, and performance. When you find that you no longer get the same effect from your preworkout or morning coffee, let AdrenoSurge restore you. References: 1. Garabadu D, Krishnamurthy S. Asparagus racemosus Attenuates Anxiety-Like Behavior in Experimental Animal Models. Cell Mol Neurobiol [Internet]. 2014 May [cited 2014 Apr 6];34(4):511–21. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24557501 2. Singh GK, Garabadu D, Muruganandam A V, Joshi VK, Krishnamurthy S. Antidepressant activity of Asparagus racemosus in rodent models. Pharmacol Biochem Behav [Internet]. 2009 Jan [cited 2014 Apr 6];91(3):283–90. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18692086 3. Krishnamurthy S, Garabadu D, Reddy NR. Asparagus racemosus modulates the hypothalamic-pituitary-adrenal axis and brain monoaminergic systems in rats. Nutr Neurosci [Internet]. 2013 Nov [cited 2014 Apr 6];16(6):255–61. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23485433 4. Joshi T, Sah SP, Singh A. Antistress activity of ethanolic extract of Asparagus racemosus Willd roots in mice. Indian J Exp Biol [Internet]. 2012 Jun [cited 2014 Apr 6];50(6):419–24. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22734253 5. Hannan JMA, Ali L, Khaleque J, Akhter M, Flatt PR, Abdel-Wahab YHA. Antihyperglycaemic activity of Asparagus racemosus roots is partly mediated by inhibition of carbohydrate digestion and absorption, and enhancement of cellular insulin action. Br J Nutr [Internet]. 2012 May [cited 2014 Apr 6];107(9):1316–23. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21899804 6. Shah J, Goyal R. Investigation of neuropsychopharmacological effects of a polyherbal formulation on the learning and memory process in rats. J Young Pharm [Internet]. 2011 Apr [cited 2013 Aug 28];3(2):119–24. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3122040&tool=pmcentrez&rendertype=abstract 7. Sharma K, Bhatnagar M, Kulkarni SK. Effect of Convolvulus pluricaulis Choisy and Asparagus racemosus Willd on learning and memory in young and old mice: a comparative evaluation. Indian J Exp Biol [Internet]. 2010 May [cited 2014 Apr 6];48(5):479–85. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20795365 8. Visavadiya NP, Soni B, Madamwar D. Suppression of reactive oxygen species and nitric oxide by Asparagus racemosus root extract using in vitro studies. Cell Mol Biol (Noisy-le-grand) [Internet]. 2009 Jan [cited 2014 Apr 6];55 Suppl:OL1083–95. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19267991 9. Patel NB, Galani VJ, Patel BG. Antistress activity of Argyreia speciosa roots in experimental animals. J Ayurveda Integr Med [Internet]. 2011 Jul [cited 2014 Apr 7];2(3):129–36. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3193684&tool=pmcentrez&rendertype=abstract 10. Habbu P V, Mahadevan KM, Kulkarni P V, Daulatsingh C, Veerapur VP, Shastry RA. Adaptogenic and in vitro antioxidant activity of flavanoids and other fractions of Argyreia speciosa (Burm.f) Boj. in acute and chronic stress paradigms in rodents. Indian J Exp Biol [Internet]. 2010 Jan [cited 2014 Apr 7];48(1):53–60. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20358867 11. Habbu P V, Shastry RA, Mahadevan KM, Joshi H, Das SK. Hepatoprotective and antioxidant effects of Argyreia speciosa in rats. Afr J Tradit Complement Altern Med [Internet]. 2008 Jan [cited 2014 Apr 7];5(2):158–64. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2816541&tool=pmcentrez&rendertype=abstract 12. Bachhav RS, Gulecha VS, Upasani CD. Analgesic and anti-inflammatory activity of Argyreia speciosa root. Indian J Pharmacol [Internet]. 2009 Aug [cited 2014 Apr 7];41(4):158–61. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2875733&tool=pmcentrez&rendertype=abstract 13. Jaiswal SK, Rao C V, Sharma B, Mishra P, Das S, Dubey MK. Gastroprotective effect of standardized leaf extract from Argyreia speciosa on experimental gastric ulcers in rats. J Ethnopharmacol [Internet]. 2011 Sep 1 [cited 2014 Apr 7];137(1):341–4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21658440 14. Kumar S, Alagawadi KR, Rao MR. Effect of Argyreia speciosa root extract on cafeteria diet-induced obesity in rats. Indian J Pharmacol [Internet]. 2011 Apr [cited 2014 Apr 7];43(2):163–7. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3081454&tool=pmcentrez&rendertype=abstract 15. Kongkeaw C, Dilokthornsakul P, Thanarangsarit P, Limpeanchob N, Norman Scholfield C. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. J Ethnopharmacol [Internet]. 2014 Jan 10 [cited 2014 Apr 1];151(1):528–35. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24252493 16. Chowdhuri DK, Parmar D, Kakkar P, Shukla R, Seth PK, Srimal RC. Antistress effects of bacosides of Bacopa monnieri: modulation of Hsp70 expression, superoxide dismutase and cytochrome P450 activity in rat brain. Phytother Res [Internet]. 2002 Nov [cited 2014 Apr 7];16(7):639–45. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12410544 17. Benson S, Downey LA, Stough C, Wetherell M, Zangara A, Scholey A. An Acute, Double-Blind, Placebo-Controlled Cross-over Study of 320 mg and 640 mg Doses of Bacopa monnieri (CDRI 08) on Multitasking Stress Reactivity and Mood. Phytother Res [Internet]. 2014 Apr [cited 2014 Apr 7];28(4):551–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23788517 18. Hung SK, Perry R, Ernst E. The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials. Phytomedicine [Internet]. 2011 Feb 15 [cited 2013 Sep 21];18(4):235–44. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21036578 19. Maslova L V, Kondrat’ev BI, Maslov LN, Lishmanov IB. [The cardioprotective and antiadrenergic activity of an extract of Rhodiola rosea in stress]. Eksp Klin Farmakol [Internet]. [cited 2014 Apr 7];57(6):61–3. Available from: http://www.ncbi.nlm.nih.gov/pubmed/7756969 20. Edwards D, Heufelder A, Zimmermann A. Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms--results of an open-label study. Phytother Res [Internet]. 2012 Aug [cited 2013 Oct 7];26(8):1220–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22228617 21. Olsson EM, von Schéele B, Panossian AG. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Med [Internet]. 2009 Feb [cited 2014 Apr 2];75(2):105–12. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19016404 22. Perfumi M, Mattioli L. Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice. Phytother Res [Internet]. 2007 Jan [cited 2014 Apr 7];21(1):37–43. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17072830 23. Huang S-C, Lee F-T, Kuo T-Y, Yang J-H, Chien C-T. Attenuation of long-term Rhodiola rosea supplementation on exhaustive swimming-evoked oxidative stress in the rat. Chin J Physiol [Internet]. 2009 Oct;52(5):316–24. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20034236 24. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med [Internet]. 2012 Jul [cited 2013 Sep 3];34(3):255–62. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3573577&tool=pmcentrez&rendertype=abstract 25. Bhattacharya SK, Muruganandam A V. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Pharmacol Biochem Behav [Internet]. 2003 Jun [cited 2014 Apr 7];75(3):547–55. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12895672 26. Singh N, Bhalla M, de Jager P, Gilca M. An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda. Afr J Tradit Complement Altern Med [Internet]. 2011 Jan [cited 2013 Sep 20];8(5 Suppl):208–13. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3252722&tool=pmcentrez&rendertype=abstract 27. Siripurapu KB, Gupta P, Bhatia G, Maurya R, Nath C, Palit G. Adaptogenic and anti-amnesic properties of Evolvulus alsinoides in rodents. Pharmacol Biochem Behav [Internet]. 2005 Jul [cited 2014 Apr 7];81(3):424–32. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15899513 28. Nahata A, Patil UK, Dixit VK. Effect of Evolvulus alsinoides Linn. on learning behavior and memory enhancement activity in rodents. Phytother Res [Internet]. 2010 Apr [cited 2014 Apr 7];24(4):486–93. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19610035 29. Malik J, Karan M, Vasisht K. Nootropic, anxiolytic and CNS-depressant studies on different plant sources of shankhpushpi. Pharm Biol [Internet]. 2011 Dec [cited 2014 Apr 7];49(12):1234–42. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21846173 30. Gupta A, Raj H, Karchuli MS, Upmanyu N. Comparative evaluation of ethanolic extracts of Bacopa monnieri, Evolvulus alsinoides, Tinospora cordifolia and their combinations on cognitive functions in rats. Curr Aging Sci [Internet]. 2013 Dec [cited 2014 Apr 7];6(3):239–43. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23866011 31. Kumar M, Ahmad A, Rawat P, Khan MF, Rasheed N, Gupta P, et al. Antioxidant flavonoid glycosides from Evolvulus alsinoides. Fitoterapia [Internet]. 2010 Jun [cited 2014 Apr 7];81(4):234–42. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19748554 32. Gupta P, Sharma U, Gupta P, Siripurapu KB, Maurya R. Evolvosides C–E, flavonol-4’-O-triglycosides from evolvulus alsinoides and their anti-stress activity [corrected]. Bioorg Med Chem [Internet]. 2013 Mar 1 [cited 2014 Apr 7];21(5):1116–22. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23357036 33. Gupta P, Akanksha, Siripurapu KB, Ahmad A, Palit G, Arora A, et al. Anti-stress constituents of Evolvulus alsinoides: an ayurvedic crude drug. Chem Pharm Bull (Tokyo) [Internet]. 2007 May [cited 2014 Apr 7];55(5):771–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17473466 These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease or illness. AdrenoSurge Supplement Facts Serving Size: 1 Capsule Servings per Container: 60 Amount Per Serving % Daily Value Asparagus Racemosus Extract 100 mg 4,000% Argyreia speciosa Extract 100 mg ** Bacopa monnieri 20:1 100 mg ** Rhodiola rosea (8% Rosavins) 100 mg ** Ashwagandha 20:1 100 mg ** Bovine Adrenal Extract 150 mg ** Evolvulus Alsinoide Extract 100 mg ** * Percent Daily Values are based on a 2000 calorie diet. ** Percent Daily Values not established. OTHER INGREDIENTS: Rice Flour & Gelatin. AdrenoSurge Directions: Take 1 serving in the morning and 1 serving before bed. AdrenoSurge WARNING: Not for use by individuals under the age of 18 years. Do not use if pregnant or nursing. Do not use if you have had a myocardio infarction (heart attack). You should not take this product if you have any prior medical condition, including diabetes or high blood pressure, or if you are taking any over-the-counter or prescription drugs. Consult your doctor before using this product. Keep out of reach of children and animals. Store in a dry and cool place.
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