Tomatidine directly promotes the activity of mTOR signalling in skeletal muscle, inhibits the ATF4 pathway, and dramatically stimulates protein synthesis. Of particular benefit to power athletes and bodybuilders is the fact that it stimulates growth primarily in Type IIb and Type IIx muscle fibers -- the power fibers with the most potential for growth. In a direct comparison to the highly regarded natural anabolic known as ursolic acid, tomatidine was shown to be nearly 10x more potent and nearly 5x more orally bio-available.
Although tomatidine is, as previously mentioned, more orally bioavailable than ursolic acid, it still displays extremely poor aqueous solubility -- estimated at 0.000189 mg/mL -- which places hard limits on its oral bio-availability. To sidestep this issue Antaeus Labs has complexed tomatidine with shilajit into Titan. Shilajit, which has been used as a tonic and rejuvenating agent for centuries, is a fully water-soluble mixture of fulvic acids, humic acids, and minerals. Much like cyclodextrins, it is capable of binding small molecules like tomatidine and forming amorphous, water-soluble complexes. Our tomatidine-shilajit complex is orders of magnitude more water-soluble than pure tomatidine, a fact which boosts its bio-availability to heights otherwise out of reach.
While shilajit was primarily included to greatly boost bio-availability, as a bonus it has itself been shown to assist with muscle growth, and boost testosterone levels in healthy young men. This further increases the muscle building and strength capabilities of Titan! Titan by Antaeus Labs has been rigorously tested, results have been made public, and a patent is pending. Titan uses top-quality tomatidine (standardized to over 95% purity) and shilajit (standardized to 50%+ fulvic acids).